Tumor-specific T-cell tolerance is one of the major barriers in cancer immunotherapy. Provision of toll-like receptors (TLR) signals significantly enhances the efficacy of tumor vaccines in treating pre-establish murine lymphoma, suggesting an essential role of TLR signals in cancer immunotherapy. The goal of the study is to determine the relationship between TLR signals, regulatory T cells, and tumor specific immunity in vivo, and explore the rational vaccine strategies in the context of murine tumor models as well as human Hodgkin's lymphoma.

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