One of the most important subjects of a cancer vaccine is how to maximize its potency. Recent studies have suggested that LIGHT, a molecule belonging to the tumor necrosis factor superfamily, induces potent anti-tumor immunity by a unique mechanism that facilitates both migration and activation of lymphocytes at the site of the tumor. In this study, we will delineate the molecular-based mechanism of this phenomenon to develop a more efficient vaccine, and lay the foundation of translational studies on LIGHT-based cancer gene therapy.

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