This study is based on the genetic modification of normal brain cells to create an environment that prevents tumor growth. Adeno-associated virus [AAV] vectors will be used to introduce in normal brain cells, or in blood vessels, a gene that makes a protein that is selectively active against tumor cells. These experiments will investigate the efficiency of this therapy principle. These approaches may lead to the creation of widespread anti-tumor networks capable of preventing brain tumors from growing or appearing again after surgery.

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