Prostate Cancer is the second leading cause of cancer death among men in the United States. We are studying and testing a new means of inhibiting the formation of prostate tumors, using an agent called TRAIL to induce the death of tumor cells. The TRAIL gene is transferred into a cell with Ad5-TRAIL, a genetically engineered virus known as a viral vector. The vector used the cell’s own machinery to produce the TRAIL protein and induce tumor cell death. Studies with laboratory animals have shown that this form of gene therapy results in the death of tumor cells. My lab currently is studying Ad5-TRAIL’s ability to activate the immune system’s anti-tumor responses. Tumor cells can deceive the body’s immune system into perceiving them as normal cells rather than foreign invaders, but introducing genes into a tumor can counteract this. Determining the effect of Ad5-Trail-induced apoptosis (programmed cell death) on the activation of the immune system in patients with localized prostate cancer is the next step in this ongoing research, and is anticipated to begin this year. The goal is to use this type of gene therapy to achieve tumor rejection, and tumor-free survival for the patients.

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