Ovarian cancer is one of the most common and frequently life-threatening malignancies affecting women in the U.S. today: about 25,000 new cases will be diagnosed with the disease this year and over 15,000 women will die from it. Delivering therapeutic genes efficiently and precisely, so that they reach only the targeted cancer cells, is crucial to success. My group has developed a means of delivering therapeutic genes to a specific population of cells in laboratory experiments. By rearranging the genetic structure of AAV, a common human virus, we have created a class of molecular Trojan horse viruses, known as vectors, from the Latin "to carry". These vectors are aimed at ovarian cancer cells via key sequences in the virus shell that allows it to infect only cells in the body displaying a particular marker that is restricted to cancer cells. We are now testing the Trojan horse system's ability to cure ovarian cancer in laboratory animals. If these studies are successful, this research will help pave the way for clinical trials in women with ovarian cancer and may lead to a new approach to this deadly disease.

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